In vitro dynamic blood-brain barrier culture system

• 详细介绍
• 详细参数

• 详细介绍

  Flocel Incs dynamic blood-brain barrier culture system has more than 20 years of world-class technology and expertise in flow-based 3D cell culture, transendothelial resistance (TEER) measurement and fluid perfusion. Our technology surpasses and is compatible with Endohm cell incubators and other Transwell products and can also cultivate other types of physiological barriers in vitro.

  
  

  
  

  Detailed introduction:

   Researchers have tested it using static BBB models or animal models. Compared with these methods, the advantages of Flocels DIV-BBB dynamic model:

  
  

     ·More accurate pharmacokinetic and toxicological research

     · More accurately reflect the characteristics of the blood-brain barrier in the body

     · Simulate endothelial cell-astrocytic interaction

     · Electrical measurement of the integrity of the blood-brain barrier

     · Can use real human-derived cells

     · Form a tighter connection than the existing static model

     · Can significantly reduce the cost of drug development

     · Trans-endothelial resistance can reach more than 1000 ohm-cm

  concrete application:

   Through completeness and transparency, we want to convey the advantages of our DIV-BBB 3.0 system compared to other methods (such as Transwell instruments). Exposure to intraluminal blood flow is essential to promote endothelial cell differentiation and increase the tightness of the blood-brain barrier. Compared with the Transwell device, endothelial cells grown under dynamic conditions develop in a single layer, thereby mimicking the structural physiology of capillaries in the body.

  
  

  
  

  Comparative studies have shown that the development of cell barriers cultured in a static flow environment (Transwell) and a dynamic flow environment (dv-bbb) is quite different. The transendothelial resistance (TEER) value of DIV-BBB culture (B) was 10 times higher than that of Transwell culture (A). In addition, the values detected in the dv-bbb culture are closer to those observed in vivo, because the dynamic flow exerts shear stress on the top surface of the cells, which affects the development and function of the cells.

  DiV-bbb reproduces the drug permeability of the brain in the body. Note that the movement of phenytoin sodium on DIV-BBB and rat brain BBB is almost the same.

  
  

   The cell barrier cultured under dynamic flow conditions, such as the cell barrier cultured in dip-bbb, is stronger than the cell barrier cultured under static flow conditions, physiologically more accurate, and tighter regulation of selective permeability. The permeability of Transwell (D) to the epilepsy drug phenytoin is significantly higher than that of divi-bbb (C), and is 4 times higher than the permeability of 0.0001 cm/s in the body. A stronger and more physiologically accurate cell barrier cultured under dynamic liquid conditions can more accurately test the permeability and pharmacokinetics of drugs.

  
  

• 详细参数

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。

• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。