eNuvio- OMEGA chips & EB 3D Cell Culture Products

• 详细介绍
• 详细参数

• 详细介绍

  Basic introduction

  The OMEGA series features powerful neuronalco-culture and compartmentalization devices that let you go further!

  To increase your data output, we created a uniqueopen chamber design so that each experimental unit consists of only twochambers separated by microfluidic microchannels. Thanks to this streamlineddesign, OMEGA devices feature more experimental units per area thanconventional microfluidic devices for neurons!

  To suit all your needs, we continuously grow ourneuronal co-culture device portfolio: from two experiments per device all theway to HTS-compatible microplates with 48 experiments ideal for drug screeningassays!

  Not only did we design this series to increaseyour data output, but also to make the devices easy to use! That’s why alldevices come ready-to-go and pre-bonded!

  
  

  EB-PLATE. Generate and analyze countlessself-assembled spheroids with our completely reusable EB-PLATE. We designedthis HTS-compatible spheroid microplate to offer you a zero-waste alternativeto single-use plastic round bottom microplates. EB-PLATEs featurestandard-sized frames with autoclavable, biologically inert, non-degradable andnon-toxic inserts. The unique well design enables the highly reproduciblegrowth of uniform EBs right in the center of the well! Although the plates areoptimized for automated screening platforms, they are also a greatenvironmentally friendly option for anybody who only needs to use a few wellsat a time. When you are done, simply renew and reuse the microplate over andover and avoid tons of garbage!

  
  

  
  

  
  

  
  

  
  

  ProductDetails

  OMEGA-4

  The OMEGAseries features powerful neuronal co-culture and compartmentalizationdevices that let you go further!

  To increaseyour data output, we created a unique open chamber design so thateach experimental unit consists of only two chambers separatedby microfluidic microchannels. Thanks to this streamlined design, OMEGAdevices feature more experimental units per area than conventionalmicrofluidic devices for neurons!

  To suit allyour needs, we continuously grow our neuronal co-culture device portfolio:from two experiments per device all the way to HTS-compatiblemicroplates with 48 experiments ideal for drug screening assays!

  Not only didwe design this series to increase your data output, but also to make thedevices easy to use! That’s why all devicescome ready-to-go and pre-bonded!

  
  

  OMEGA-ACE

  The twochambers of the OMEGA device aren’t enough for your co-culture andcompartmentalization experiments? For more flexibility, we designedthe OMEGAACE triple chamber neuronal co-culture andcompartmentalization device series!

  Eachexperimental unit features three serially-adjoined culture chambers that arephysically separated by microfluidic microchannels.

  Choose betweendifferent chamber sizes and device formats: from a single experiment per deviceall the way to HTS-compatible microplates with 32 experiments idealfor drug screening assays. We’ve got you covered!

  Of course, allOMEGAACE devices have open chambers and come pre-bonded to glass andready-to-go so you can start your experiments right away!

  
  

  OMEGA-AG

  We designedthe OMEGAAG device to help you easily study axonguidance and chemotactic factors in vitro. This advancedmicrofluidic device for neurons has 4 chambers that are each connected toa central viewing area via a series of microfluidic microchannels.Thanks to these microchannels, you can easily establish uniform gradients ofchemotactic factors in the viewing area and perform axon guidanceexperiments such as growth cone turning assays.

  Of course,just like our OMEGA series, the OMEGAAG devices feature openchambers for even more versatility and come ready-to-go and pre-bonded to glassso you can start your experiments right away!

  
  

  OMEGA-NMJ

  Eachexperimental unit of this specialized microfluidic co-culture device consistsof one neuronal chamber and one muscle chamber connected bymicrochannels. To aid the formation of stable and mature 3D skeletalmuscle microtissue, the muscle chamber contains twobuilt-in micropillars that serve as anchor points.

  TheOMEGANMJ employs microfluidic microchannels to fluidicallyisolate the adjacent chambers. This provides physical distance betweenthe neuron and skeletal muscle cultures while allowingneuronal axonal projections full access to the 3D muscle tissue.

  Each OMEGANMJ featurestwo experimental units so you can easily collect more data. As always, alldevices come ready-to-go and pre-bonded!

  
  

  OMEGA-MP

  Advanceyour skeletal muscle research projects and implement new 3D cellculture technologies with our OMEGAMP 3D skeletal muscle device series!

  Each culturechamber of OMEGAMP contains two built-in micropillars that serve asanchor points for the 3D muscle culture. Simply watch your cells self-assembleinto a stable and mature skeletal muscle microtissue (see video belowfor an example). Once sufficiently matured, these 3D microtissues twitch andcontract as you would expect from skeletal muscle.

  
  

  EB-DISK/EB-PLATE/ EB-CLARIFY96 3D Cell Culture Products

  EB-DISK

  Formcountless self-assembled embryoid bodies(EBs) or spheroids with our EB formation devices. Wedesigned the EB-DISKs to facilitate growing large quantitiesof uniform EBs on a small footprint without requiring much of yourtime.

  Theunique microwell design ensures highly reproducible growth ofspheroid cultures. EB-DISKs are available in  137, 360 or948 microwell format so you can easily grow up to 948 EBs in a singleculture dish. Best of all? Change the media for all EBs in just a fewseconds! Transferring EBs is rapid and gentle too! And if you want,renew and reuse the EB-DISK!

  
  

  EB-PLATE

  Generate andanalyze countless self-assembled spheroids with ourcompletely reusable EB-PLATE. We designedthis HTS-compatible spheroid microplate to offer youa zero-waste alternative to single-use plastic round bottommicroplates.

  EB-PLATEsfeature standard-sized frames with autoclavable, biologically inert,non-degradable and non-toxic inserts. The unique well design enables the highlyreproducible growth of uniform EBs right in the center of the well!

  Although theplates are optimized for automated screening platforms, they are also a greatenvironmentally friendly option for anybody who only needs to use a few wellsat a time. When you are done, simply renew and reuse the microplate over andover and avoid tons of garbage!

  
  

  EB-CLARIFY96

  Protectdelicate spheroids during processing

  • Automate EBformation, immunolabelling, tissue clearing and imaging for 48 spheroids in a96-well microplate format

  • Microfluidicchannels between chambers limit the intensity of solution exchange betweenwells to protectthe integrity of delicate spheroids/organoids

  • Full HTSIntegration:

  • Employautomatic plate washing equipment and pinning tools to meet throughput needs

  • Imagedirectly after processing – no transfers

  necessary

  • Flat, clearbottom for high quality microscopy and high-content screening compatibility

  
  

  ADVANTAGES OF EB-DISK/ EB-PLATE/ EB-CLARIFY96

  Enables large scale spheroid/organoid production while saving time, spaceand cost

  All-in-one devices for end-to-end 3D culture experimentation

  Designed to be use in high-throughput screening settings

  Completely reusable

  
  

  Applications

  NEURONAL COMPARTMENTALIZATION

  Neurons seeded in a single chamber of the OMEGA device will project theirneurites through the microchannels into the adjacent chamber. Fluidic isolationof one chamber from the other by controlling the direction of the pressure headthrough the microchannels allows for the fluidic separation of neuronal somasfrom their projecting axons. Each of these neuronal components can then betreated and analyzed separately.

  
  

  COMPARTMENTALIZED UPTAKE EXPERIMENTS

  Examine compartment-specific uptake, intraneuronal transport, andpropagation of toxic or misfolded proteins such as tau, amyloid-β, α-synuclein,TDP43, or prion PrP. The fluidic isolation of compartments with the OMEGAdevice stops the extracellular travel of applied molecules to the adjacentcompartment, providing researchers with the utmost confidence in theinterpretation of results.

  
  

  CO-CULTURE APPLICATIONS

  Motor neurons/ skeletal muscle co-culture. Motor neuron somas never come into direct contactwith skeletal muscle. Instead, study a physiologically relevant neuromuscularjunction using OMEGA devices. Ideal for neuromuscular disorder applicationssuch as ALS and Kennedy’s disease (SBMA).

  Otherco-culture applications:

  Nigrostriatalpathway - Dopaminergic neurons / GABAergic neurons: Replicate this classicdopaminergic pathway in vitro for Parkinson’s disease research.

  Nociceptionand mechanosensation - Co-culture sensory neurons (e.g. DRGs) adjacent toskin fibroblasts to form an excellent pain model.

  Myelination- Examine the myelination potential of oligodendrocytes co-cultured in thesomatic or axonal neuronal compartments, or both!

  Investigatethe brain-gut axis by co-culturing vagal, sympathetic or spinal afferentfibers adjacent to gastrointestinal explants or self-assembles gut organoids.

  
  

  Specifications

  The OMEGANMJ 3D Neuromuscular Junction Device starter kit contains

  • 3 x OMEGANMJ devices (individually packaged)

  • 3 x circular cell culture evaporation minimizers (blue; reusable)

  • 3 x 35 mm round culture dishes

  • 1 x microscope stage adapter (reusable)

  
  

• 详细参数

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。

• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。