Linas-M Lipid Nanoparticles Manufacturing Platform

• 详细介绍
• 详细参数

• 详细介绍

  Basic introduction:

  Original microfluidic device Linas-M fordevelopment and manufacturing of well-size-controlled functional lipidnanoparticles. Other company’s’ conventional mixer devices focus on quickmixing, and as a result, they can produce small particles even at a low flowrate condition. But the range of particle size change in response to flow ratechange is narrow.

  On the other hand, the iLiNP does not inducerapid mixing at a low flow rate, and the change in particle size as a functionof flow rate is gradual. As the flow rate is increased, a local vortex isappeared and dilution is accelerated, even in the flow rate range where mixingand dilution performance is normally saturated. As a result, the range ofparticle size change in response to flow rate change is very wide. Size controlrange is 20-150 nm.

  
  

  
  

  
  

  
  

  Advantages & Key Functionalities

  lReservoir tanks and high precisionsyringe pumps are built-in. Using a small amount of reagent, particleprototypes with high flow rate precision and high manufacturing reproducibilityare possible.

  lThe microfluidic chips with various flow path shapes can be used(customization is chargeable). Up to 4 ports can be used for inlets / outlets.

  lBuilt-in control computer eliminates the need for an external PC.Easy operation by anyone with a touch panel interface.

  lThe microfluidic chips can be set by simply placing it on the stageand lifting up. This contributes to improve reproducibility without the needfor troublesome piping operations.

  
  

  Application：

  Preparation of large-size particles

  The reason why the iLiNP can easily producelarge particles (>80 nm for a typical lipid composition), although the othercompany’s technologies cannot, is because of the different mixing strategy ofthe ingredients.

  The iLiNP (shown in the above figure) adopt astrategy of no-whole & no-rapid mixing of the ingredient at a typical flowcondition. As a result, the liquid-liquid interface, where self-assembly of thelipids proceeds, is maintained for a long time, and large particles can beobtained (<200 nm for a typical lipid composition, <500 nm if the lipidcomposition is also modified).

  
  

  Preparation of small-size particles

  Under a high flow condition, the channelstructure adopted in the iLiNP generates a local vortex (local mixing) in theflow channel while maintaining the interface as shown in the above figure.

  As a result, local dilution is acceleratedonly under the high flow rate conditions, and small particles can be obtained.The efficiency is so high that even smaller particles than those produced byother technologies can be obtained at a flow rate of about 1/10 that of othertechnologies.

  
  

  
  

• 详细参数

  Linas-M General Data：

  LipidNanoparticles Manufacturing Platform LiNAS-M Specifications

  Model: LM-001

  Power: AC220V（50/60Hz）

  Dimensions：250(W)×300(D)×408(H)ｍｍ(Excluding protrusions)

  Weight: Approx.10 kg

  Configurations: ①Main unit ②Transparent cover

  Standard accessories: Instruction manual,Plastic frame for the microfluidic chip

  Number of syringe pump: 2 set

  Resolution of syringe pump: 0.5μm / step

  Standard syringe / control range:

  Syringe A : 5.0ml Volume : 0 ~ 5,000μl Flowrate : 25 ~ 10,000μl/min

  Syringe B : 5.0ml Volume : 0 ~ 5,000μl Flowrate : 25 ~ 10,000μl/min

  (User exchangeable / customizable differentcapacity)

  Compatible syringe: ITO micro syringe MS-UNF500and etc.

  Tubing: Tube 1/16“ OD (φ1.6ｍｍ) φ0.5 ID , built-in / replaceable

  Reservoir: JMS syringe 25ml 2 pcs （User exchangeable / customizable different capacity）

  Operation: Controlled from the built-in touchpanel (USB keyboard and USB mouse can be used)

  Applicable microfluidic chip:

  Microfluidic chip LM-iLiNP001 and etc.dedicated for LiNAS-M

  (To be used with in a special plastic frame)

  
  

  Microfluidic chip LM-iLiNP001 dedicated forLiNAS-M Specifications

  Model: LM-iLiNP001

  Dimensions: 70(W) x 30(D) x 3(H)mm (excludingthe ports）

  Material; PDMS (polydimethylsiloxane)

  Inlet / Outlet: 2 pcs / 1 pc.

  Channel structure: iLiNP® type shape（baffle mixer type structure)

  Remark: It is recommended to use it only onceafter opening to avoid performance deterioration due to contamination withdust.

  
  

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。

• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。