Fox Flash Oxidation Protein Footprinting System

• 详细介绍
• 详细参数

• 详细介绍

  Basic Introduction:

  GenNext has pioneered a superior, compact,cost-effective, and safe means of performing Hydroxyl Radical ProteinFootprinting (HRPF) analysis by replacing expensive, complicated, and hazardouslasers with our proprietary Flash Oxidation (Fox™) Protein Footprinting System in a convenientbenchtop format.

  To address reproducibility challenges, GenNexthas developed the Fox Radical Dosimeter — the world’s first OH radical measurement system thatautomatically controls the generation of effective OH radicals in the face ofunpredictable and varying background scavenging. The Fox Dosimeter providesreal-time measurement of OH radical concentration, making it simple to detectproblems with biopharmaceutical solutions or assay conditions before massspectrometric analysis is performed, vastly improving HRPF ease of use whilesimultaneously ensuring labeling confidence and fidelity.

  To eradicate present day bioinformatics and dataprocessing bottlenecks, GenNext introduces FoxWare™ Data Processing — a unique data processing program specificallytailored to aptly address and automate data processing demands of HRPF HOSanalysis.

  
  

  Product Details:

  FOX™ Radical Dosimeter

  Precisely measure hydroxyl radicalconcentration

  Superior reproducibility is achieved with theFOX Radical Dosimeter—the world’s first OH radical measurement system thatautomatically controls the generation of effective OH radical concentration inthe face of unpredictable and varying background scavenging. The Dosimeterdelivers near real-time measurement of OH radical concentration, making itsimple to detect problems with biopharmaceutical solutions or assay conditionsbefore mass spectrometric analysis is performed, vastly improving HRPFease-of-use while simultaneously ensuring labeling confidence and fidelity. TheFOX Radical Dosimeter is an in-line capillary UV photometer located immediatelydownstream of the FOX Photolysis System. Real-time photometric absorbancemeasurements during radical production are produced, enabling the assessment ofeffective hydroxyl radical concentration.

  
  

  FOX™ Automated Product Collector

  Automatically collect and deposit labeledsamples

  The FOX Automated Product Collector is aneasy-to-use compact device that automatically collects and deposits labeledsample into designated microtubes, eliminating sample collection workload whiledelivering maximum product purity.

  The Collector is controlled by the samesoftware program that also coordinates the functionalities of the Photolysis,Radical Dosimeter, and integrated microfluidics systems. This unified softwareeliminates the need to monitor photolysis processing time to insure propercollection of labeled product without undue introduction of unlabeled sample.

  User selected product volume is preciselydelivered to collection tubes containing quenching solution, enablingreproducible and predictable quenching for each labeled sample.

  
  

  FoxWare™ Protein Footprinting Software

  Easily perform comparative HOS analysis

  Present day bioinformatics and data processingbottlenecks are eradicated by GenNext FoxWare Protein FootprintingSoftware—specifically tailored to address the data processing demands of HRPFHOS analysis. Data processing of HRPF results can be agonizingly laborious. Upuntil now, researchers have been compelled to use a piecemeal approach,arduously stitching together results from multiple proteomics data analysispackages and manually manipulating data in home-brew spreadsheets. Further,while broad in scope, today’s proteomics data analysis products fail toadequately inform and fully address specific workflow, chemicallabeling/artifacts, and comparative study requirements of HRPF HOS analysis. Toaddress these shortcomings, GenNext Technologies introduces FoxWare ProteinFootprinting Software, the first commercial software exclusively tailored for

  FPOP HRPF HOS data analysis. In contrast tobroad-based, multi-purpose platforms, FoxWare HRPF Protein FootprintingSoftware specifically and aptly addresses the data processing demands of HRPFHOS analysis. The software is completely compatible with both our FOX FlashPhotolysis and laser-based FPOP

  HRPF studies. Intuitive algorithms enablingqualitative and quantitative comparative studies of HOS footprint inform andaddress key requirements in biopharmaceutical and biosimilar research.

  
  

  FOX™ HRPF Accessories

  Modules and software for lab-built HRPFsystems

  For pioneering scientists currently employinglab-made HRPF instruments,

  GenNext offers a series of accessories toaccelerate your research:

  • Radical Dosimeter Module

  • Product Collector Module

  • Module Controller

  • FoxWare Protein Footprinting Software

  GenNext’s Radical Dosimeter and ProductCollector modules are specifically designed to enable convenient integrationwith existing HRPF setups. Their small footprint enables the Dosimeter andCollector modules to be easily mounted on optical breadboards directly in-linewith existing HRPF capillary systems. The Radical Dosimeter is placedimmediately downstream of the laser photolysis region and the Product Collectorreceives the terminal end of the system’s capillary. Under software control,our Module Controller automates the entire HRPF process for more reproducibleresults. The Module Controller coordinates the activities of all of yourGenNext components, including the FOX Dosimeter and Product Collector, as wellas your system’s laser and syringe pump. The near real-time dosimetry allowsusers to monitor effective labeling before MS analysis, saving time, money, andprecious sample. Each labeling experiment can be performed flawlessly withoutthe deleterious impact of uncontrolled scavenging or human error. After MSanalysis, labeling results and HOS can be evaluated in minutes with FoxWareProtein Footprinting Software.

  Application：

  Discovery Applications

  Rx Binding Validation

  • Orthosteric

  • Allosteric

  • Conformational Change

  • GPCR cascade

  mAb Therapeutics

  • Epitope Mapping

  • Paratope Mapping

  • Affinity Determination

  Conformational Analysis

  • Confomer Detection

  • Discrete Functional Analysis

  Biosimilar Assessment

  • Candidate validation via HOS

  
  

  
  

  
  

• 详细参数

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

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• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。