Scissor N3 In Vitro Subcutaneous Injection Site Simulator

• 详细介绍
• 详细参数

• 详细介绍

  Basic Introduction:

  Scissor N3 is an in vitro model simulating subcutaneous injection of biopharmaceuticals for rank ordering formulations and excipient screening during formulation development.

  Understand in vitro how a drug behaves after subcutaneous injection and the impact this has on drug release with our Scissor N3.

  Reduce the reliance on inaccurate animal models and select formulation candidates with confidence based on bio-relevant information gained earlier in the development process, saving in both cost and time.

  The Scissor N3 mimics the stresses a biopharmaceutical experiences when transitioning from formulation conditions to a subcutaneous environment.

  Possible precipitation events can be monitored and correlated to lymphatic and systemic release dynamics quantified in the system.

  Scissor allows users to screen excipients and compare different formulations to identify the best candidates for further development.

  Compatible with an optional fraction collector.

  
  

  Product Advantages:

  SCISSOR N3 is the only commercially available scientific instrument designed as a bridge for in vivo pharmacokinetic (PK) studies and in vitro drug release and dissolution performance assessment.

  SCISSOR N3 can conduct 3 independent experiments simultaneously, while SCISSOR N6 allows for up to 6 experiments.

  Optional automatic sample collector with programmable sampling volume and frequency, featuring 240 collection positions and automatic replenishment.

  Integrated camera and turbidity sensor enable efficient turbidity detection, assessing drug precipitation or particle dissolution behavior.

  Compatible with Rainbow R6 fiber optic probes for online drug concentration monitoring, providing concentration vs. time profiles.

  Maintains physiological relevant temperature and buffered environment throughout experiments.

  Capable of monitoring pH changes at injection sites within the extracellular matrix (ECM).

  Optimal selection of ECM simulates realistic subcutaneous environments.

  
  

  Product Key Features:

  Gain biorelevant data about your subcutaneous sample in vitro

  Coupled with the Rainbow R6 in-situ fiber optic UV-vis spectrometer, lymphatic and systemic release data can be measured in-situ giving real-time results and enriching the data collection process.

  Sample aliquots can also be collected with an additional external fraction collector to allow for offline analysis with any preferred analytical method facilitating more in-depth research.

  
  

  Application：

  The Scissor N3 is an exciting branch of the Pion technology helping users understand formulations

  Excipient screening during formulation development

  Formulation comparison

  Rank ordering formulations for candidate selection

  Investigation of drug stability upon and after injection

  
  

• 详细参数

  Specification

  PH Range: 4-10, fluctuation range of +1/-0.05 pH
  Outer chamber temperature: 34°C; adjustable from 30-40°C
  Stability: +1/-1.0°C (24 hours), temperature equilibrium time <1 hour
  Camera capture speed: 2 images/minute
  Pump flow rate: >25 mL/minute
  Liquid transfer time (outer chamber to sampling point): <30 seconds
  Stirring speed: Optional
  LED wavelength: 504 nm

  
  

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。

• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。