T3 Automated platform for the determination of Physicochemical Properties

• 详细介绍
• 详细参数

• 详细介绍

  Basic Introduction:

  Automated platform for the determination of Physicochemical Properties

  Elucidate drug potential

  Globally renowned as the gold standard technique for determination of pKa, logP/D and solubility of ionisable compounds.

  Rich insights to discovery scientists allowing them to make accurate and assured decisions about their drug candidates.

  Determine pKa values using two techniques: spectrometric (for UV-active compounds) and potentiometric (for non-UV active compounds). With high throughput automated screening capabilities, SiriusT3 can complete up to 80 assays a day.

  Determine the intrinsic solubility of the different forms (crystalline and amorphous) for polymorphs compounds using the Pion’s CheqSol technique.

  
  

  Product Advantages:

  Requiring only sub-milligram sample quantities in most cases, the SiriusT3 can complete the analysis in less than 6 minutes per titration using the high throughput pKa screening**.**

  Determine pKa values using two techniques: spectrometric (for UV-active compounds) and potentiometric (for non-UV active compounds).With high throughput automated screening capabilities, SiriusT3 can complete up to 80 assays a day.‍

  Measure log P/D as a function of pH in less than 2 hours using the potentiometric technique in place of traditional shake-flask methods. Determine kinetic and intrinsic solubility using Pion’s patented CheqSol technique within two hours.

  Use the CheqSol technique to provide intrinsic solubility as a function of pH and generate detailed information about the extent and duration of the supersaturated states.

  
  

  Product Key Features:

  DTAu –Fully automated with pKa high throughput screening SiriusT3 system with both spectroscopic and potentiometric assay capabilities.

  DTu – A single vial system for one assay at a time with both spectroscopic and potentiometric assay capabilities.

  DTA – A fully automated system with only potentiometric assay capabilities.

  DT - A single vial system for one assay at a time with only potentiometric assay capabilities.

  Assay Expert – Optional integrated prediction module

  
  

  Application：

  Measurement of logP and logD.

  Measurement of extreme pKas.

  Measurement of logP for samples poorly soluble in water and octanol.

  Solubility and supersaturation.

  Determination of solubility - CheqSol explanation.

• 详细参数

  Specification

  pH Electrode: Ag/AgCl, double junction reference
  pH Range: 1.8-12.2, calibrated via Sirius Four-Plus™
  Electrode Storage: Stored in Home position; calibrated with pH 7 buffer
  Stirring: Overhead, variable speed, computer-controlled
  Temperature: Measured at each data point by thermocouple, Peltier controlled, 12℃-70℃
  Turbidity Detection: Light transmission detection - percentage of light transmission (0.1%)
  Reagents: Water, acid, base, co-solvent, dispensing solvent
  Dispensing Solvents: Up to 7 types, including n-octanol, dodecane, toluene
  Co-Solvents: Up to 10 types, including methanol, acetonitrile, DMSO, and MDM. Automated, six-way valve can add 6 types.
  Dispenser: Precision dispenser, 0.5 ml syringe, multi-capillary bundle, minimum volume 0.024 L
  Moving Probe: Fully automated X-Y axis titration module
  Cleaning: Static and dynamic cleaning stations
  Auto-Sampler: Optional, 192 sample positions, automatic mechanical gripper
  Purge Gas: 2 internal flow meters, nitrogen or argon
  Experimental Volume: 1.0-3.5 mLs
  Environmental Requirements: Indoor use, altitude ≤2000m, temperature 5℃-40℃, maximum relative humidity 80%@31℃
  Power Supply Voltage Fluctuation: +/-10%, overvoltage Cat, pollution degree 2.

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。

• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。