Magnetic hyperthermia equipment

• 详细介绍
• 详细参数

• 详细介绍

  MagneTherm™ Magnetic Fluid Hyperthermia Analysis System
  The MagneTherm™ Magnetic Fluid Hyperthermia Analysis System uses alternating magnetic fields (AMF) and magnetic nanoparticles (MNPs) as a heating method for tumors and other cells. By applying an alternating magnetic field of a certain strength, the magnetic particles can absorb electromagnetic energy and convert it into heat. The system controls the heat to be confined within the tumor tissue, leading to apoptosis and necrosis of cells, thus achieving hyperthermia treatment and related studies for tumors. This system can also control the tissue targeting and cell-specific targeting of the magnetic nanofluid, enabling extracellular and intracellular multiparametric magnetic fluid hyperthermia analysis.
  
  System Principle
  By controlling nanoscale magnetic particles to locate within tumor tissues, and then applying an external alternating magnetic field, the materials are heated due to magnetic hysteresis, relaxation, or induced eddy currents. The generated heat is transferred to the surrounding tumor tissue, increasing the temperature above 42°C, leading to apoptosis and necrosis of tumor cells, thereby achieving tumor treatment.
  The main principles by which the MagneTherm™ magnetic fluid hyperthermia testing system kills tumor cells are:
  (1) High temperatures alter the fluidity of the mitochondrial membrane in tumor cells, damaging the enzymes necessary for DNA synthesis and causing cell death. Heat also lowers the pH value of tumor tissues, enhancing the cytotoxic effects.
  (2) Tumor blood vessels are irregular and have low heat dissipation capacity, increasing the selectivity of hyperthermia for tumor tissue and enhancing NK cell activity. NK cells can kill tumor cells without being activated by tumor antigens. Their cytotoxic effect is mainly achieved by binding their surface tumor cell receptors to the tumor cells and releasing cytolysins.
  (3) It promotes the maturation of dendritic cells (DCs). Immature dendritic cells are precursors of mature dendritic cells and have strong antigen uptake capabilities. However, due to their low expression of MHC I, II and co-stimulatory molecules, they cannot effectively present antigens to T lymphocytes, resulting in reduced T cell stimulation. Mature dendritic cells can significantly stimulate initial dendritic cells to proliferate, making dendritic cells the initiators of immune responses.
  (4) Magnetic fluid hyperthermia can also increase the expression of MHC I on tumor cell surfaces, thereby activating T cell-mediated anti-tumor immune responses.
  
  The figure above compares the heating performance of magnetic fluids (Fe3O4) at different concentrations in an alternating magnetic field.
  Product Advantages
  This MagneTherm™ system exceeds the safe and tolerable magnetic field dosage and is highly flexible, allowing researchers to change frequency and field strength as needed for different cell and tissue systems. It enables magnetic fluid hyperthermia analysis of cells (adherent or suspended) and 3D cell culture systems.
  Ten different standard frequencies, ranging from 50 kHz to 1 MHz
  Including 110 kHz, 168 kHz, 176 kHz, 262 kHz, 335 kHz, 474 kHz, 523 kHz, 633 kHz, 739 kHz, 987 kHz
  Magnetic field strength up to 25 mT, adjustable
  Excellent thermal insulation
  Compatible with PCR vials or small tubes (volumes from 1 mL to 50 mL)
  Can operate with 35 mm culture dishes (biofilm/cell/3D tissue culture)
  Desktop unit with minimal footprint
  Lightweight low-temperature cooling system without bulky attachments
  
  Application Fields
  Small Animal Tumor Therapy Research
  Existing studies have shown that magnetic hyperthermia can achieve effective targeted intratumoral therapy, unaffected by tumor size or location. In recent years, the discovery of the "thermal bystander" effect of magnetic hyperthermia has attracted widespread attention. Various magnetic materials used for hyperthermia have become a research hotspot globally.
  
  Heat Shock Protein Research
  Combining hyperthermia with chemotherapy drugs can enhance immune function while avoiding the toxic side effects of radiotherapy and chemotherapy. Heat shock proteins (HSPs), particularly HSP70, mainly participate in the processing and presentation of tumor antigens. They can directly present tumor antigen peptides to T cells as antigen-presenting molecules, activating T cell-mediated cellular immunity. The interaction between immune capacity and tumors is mutual: the immune system affects tumor development, and tumors can alter immune function. In the treatment of malignant tumors, besides surgery, chemotherapy and radiotherapy are the main methods. However, due to drug resistance and dose limitations, these treatments can also damage normal tissues and cells, potentially causing life-threatening complications.
  Drug Release Control Research
  Controlled drug release technologies ensure slow and sustained efficacy, maintaining optimal drug concentrations in the blood to achieve the best therapeutic effect. Their advantages include better absorption and metabolism of drugs and optimized therapeutic effects. By using specially designed magnetic nanoparticles to carry drugs, drug release can be better controlled. The system enables drug penetration into solid tumors, and when combined with magnetic fluid hyperthermia analysis, it allows targeted drug release to kill cancer cells precisely at the targeted site.
  
  Biofilm Treatment Mediated by Magnetic Nanoparticles
  Bacterial colonies attach to surfaces and form biofilms by secreting extracellular polymeric substances. Biofilm formation provides antibiotic resistance and promotes the development of chronic infections. The application of superparamagnetic iron oxide nanoparticles (SPIONs) significantly reduces the risk of biomaterial-associated infections. The magnetic targeting ability of SPIONs allows them to penetrate biofilms. Using an alternating magnetic field to heat the particles reduces bacterial colony viability. This approach is particularly effective against antibiotic-resistant strains and biofilms, showing great promise in treatment.
  Magnetic Fluid Nanoparticle Types in Use Include:
  Surface-functionalized magnetite (Fe3O4)
  Silver-coated hematite (iron oxide)
  Magnetite (Fe3O4)
  Cobalt-doped magnetite
  Iron core/iron oxide shell nanoparticles
  Gold-coated hematite (iron oxide)
  Iron oxide nanocrystals (IONCs)
  Colloidal greigite (Fe3S4) nanosheets
  

• 详细参数

  System Components
  Includes DC power supply system, function signal generator, oscilloscope, etc.
  DC Power Supply System: 24 cm (W) × 32 cm (D) × 13 cm (H)
  Weight: 6 kg
  Function Signal Generator: 22 cm (W) × 29 cm (D) × 10 cm (H)
  Weight: 2.8 kg
  Oscilloscope: 35 cm (W) × 44 cm (D) × 17 cm (H)
  Weight: 8 kg
  Main Accessories
  17-turn coil
  9-turn coil
  Thermocouple adapter with multimeter function
  Oscilloscope
  Function signal generator
  Temperature probe (T-type thermocouple)
  DC regulated power supply
  Polystyrene sample tubes
  Tubing and gaskets
  Cooling water connecting tubes
  Connection cables
  Table 1: Frequencies and Magnetic Field Strengths Provided by the System
  
  Note: All field strengths can be adjusted by the operator from the maximum down to zero.
  
  Above: Winding method of 17-turn and 9-turn coils
  Optional Accessories:
  Larger sample coil box (60 mm)
  Low-frequency accessories: 90 kHz, 87 kHz, 70 kHz, 64 kHz, 50 kHz
  Water-jacketed sample aperture (commonly used for in vivo applications)
  Dual-channel optical fiber signal processor and temperature probes
  

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。

• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。