Dynamic Physiological Microenvironment Barrier-on-Chip System

• 详细介绍
• 详细参数

• 详细介绍

  Basic Information
  Organs-on-Chip are bioengineered in vitro models that closely mimic the structure and function of human organs. By modelling the smallest functional unit of the organ, they enable the simulation of human physiology. Organs-on-chip will reduce drug attrition rate and animal testing.
  Our barrier-on-chip allows the modeling of a wide range of tissue barriers. The soft cell culture substrate facilitates cell attachment and the establishment of tight mono- and co-cultures.
  At AlveoliX, everything is engineered to be “as simple as possible, but not simpler”. Inspired by nature, we develop our organs-on-chip by combining expertise in microfluidics and cell biology. The innovative chip design allows accurate cell seeding, easy multi-time point sampling, and barrier integrity measurements. It is perfectly suitable for modeling various tissue barriers such as lung, gut, skin, brain, kidney, etc. using cell lines, induced pluripotent stem, or primary cells
  
  Product Advantages:
  1.Highly Biomimetic with Physiological Mechanical Simulation
  Accurately replicates human organ microenvironments, including gas exchange, nutrient flow, and mechanical stretching (e.g., lung breathing).
  2.Reduction in Animal Testing, Enhanced Predictive Power
  Offers more reliable preclinical results compared to traditional 2D/3D cultures; improves drug efficacy and toxicity predictions.
  3.High-Throughput and Precision Control
  Microfluidic systems allow fine-tuned control over shear stress, pressure gradients, and flow rates, enabling standardization and scalability.
  
  
  Main Product Features:
  The AXBarrier-on-Chip System includes customizable stretch parameters to replicate mechanical cues of any organ barrier.
  Uni- or Bidirectional membrane movement --Create any motion pattern of your choice
  Physiological and Pathophysiological stretch levels --Create physiological motion or simulate traumas / injuries
  Frequency adjustments--Speed up or slow down the motion to target the desired stimuli
  Active and dormant time periods definition --Tune the organ motion to account for day and night activit
  Ultrathin, porous and elastic membrane for cell growth --Thickness: 3.5µm & Pores: Ø 3µm
  Mono- or Coculture models--with/without immune component
  Application Areas:
  Drug screening and toxicity testing
  Disease modeling and mechanism studies
  Precision medicine and personalized drug response
  Alternatives to animal testing
  Multi-organ interaction studies and pharmacokinetics modeling
  
  
  Specification
  About Exchanger
  The AXExchanger is connected to the AXDock inside the cell culture hood. It pneumatically controls the valves of the AX12, located between the inlet well, the cell culture chamber and the outlet well. By opening and closing the valves, a controlled fluid flow is created for initial chip filling and medium exchange. The AXExchanger also allows the measurement of TEER in combination with a suitable equipment. It is operated via a touch screen interface and an intuitive software.
  About AXActuator
  The AXActuator is connected to the second AXDock placed in the incubator. It pneumatically controls the movement of the membrane inside the AX12, recreating the cyclic stretch motion. The parameters can be easily modified in the interface. The AXActuator is controlled via a touch screen interface and an intuitive software. Experimental data can be exported to a USB flash drive for documentation.
  About Chip Membrane
  The elastic and ultrathin membrane is a key component of our lung-on-chip. It enables the 3D cyclic stretch and serves as a soft cell culture support for optimal cell attachment. Our biocompatible silicone membrane allows many different ECM coatings. The 3.5 μm thin membrane has 3 μm pores at a density of 800000 pores/cm2.
  About Breathing Motion
  Our patented 3D breathing concept applies human lung physics. The ultrathin membrane is deflected by negative pressure inside the basal chip chamber through an integrated micro-diaphragm. In this way, cells cultured on the membrane get constantly stretched and biomechanically stimulated.
  

  
  

• 详细参数

  Specification
  About Exchanger
  The AXExchanger is connected to the AXDock inside the cell culture hood. It pneumatically controls the valves of the AX12, located between the inlet well, the cell culture chamber and the outlet well. By opening and closing the valves, a controlled fluid flow is created for initial chip filling and medium exchange. The AXExchanger also allows the measurement of TEER in combination with a suitable equipment. It is operated via a touch screen interface and an intuitive software.
  About AXActuator
  The AXActuator is connected to the second AXDock placed in the incubator. It pneumatically controls the movement of the membrane inside the AX12, recreating the cyclic stretch motion. The parameters can be easily modified in the interface. The AXActuator is controlled via a touch screen interface and an intuitive software. Experimental data can be exported to a USB flash drive for documentation.
  About Chip Membrane
  The elastic and ultrathin membrane is a key component of our lung-on-chip. It enables the 3D cyclic stretch and serves as a soft cell culture support for optimal cell attachment. Our biocompatible silicone membrane allows many different ECM coatings. The 3.5 μm thin membrane has 3 μm pores at a density of 800000 pores/cm2.
  About Breathing Motion
  Our patented 3D breathing concept applies human lung physics. The ultrathin membrane is deflected by negative pressure inside the basal chip chamber through an integrated micro-diaphragm. In this way, cells cultured on the membrane get constantly stretched and biomechanically stimulated.
  

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。

• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。