In Vivo Imaging and Screening Device for C. elegans 

• 详细介绍
• 详细参数

• 详细介绍

  Compared to in vitro cell-based assays, nematodes and other small model organisms offer many advantages in drug discovery and toxicological chemical library phenotypic screening, genetic screening, and human disease modeling. However, due to the fine nature of the research subjects or the inability to perform phenotypic analysis, such studies can be difficult to implement. Using VivoChip can solve these problems for you. The worms will be immobilized under a #1.5 coverslip, making them ideal for imaging with any objective lens or light source. Once imaging is complete, the worms can be recovered and released from the chip; the device can also be reused for future experiments if properly cleaned.

  VivoChip is a simple-to-use, elegantly designed microfluidic device with precisely defined channel geometry, allowing lateral alignment and anesthetic-free immobilization of up to 40 C. elegans or other nematodes for high-resolution imaging under any microscope. Depending on user needs, vivoChips are available in various sizes, from microscope slide formats with 2x40 individual devices to multi-well plate formats with 24x40 devices.

  

  Product Advantages

  Rapid immobilization of C. elegans

  Load and immobilize 40 C. elegans or other nematodes in the same orientation within minutes, reducing the need for anesthetics.

  Compatible with any microscope

  Compatible with nearly all imaging systems, whether inverted, upright, confocal, 2x or 100x, brightfield or fluorescence microscopes.

  Chips available for various worm stages

  Chips are available for all stages from L1 larvae to D5 adults, allowing immobilization of nematodes of any size needed for your research.

  Easy control with VivoCube+

  VivoCube+ provides automatic pressure control for microfluidics, with built-in programs designed for various types of nematode chips. Easy to learn and use.

  Designed for fast high-resolution imaging and phenotypic analysis

  Research subject too fine? Unable to perform phenotypic analysis? Use vivoChip-2x to solve these problems. The worms will be immobilized under a #1.5 coverslip, making them ideal for imaging with any objective lens or light source. Once imaging is complete, the worms can be recovered and released from the chip; the device can also be reused for future experiments if properly cleaned.

  Application Notes

  Below are some example images of research applications enabled by vivoChip-2x. If you are curious about how this system can help your research, please contact our experts to discuss your ideas!

  

  Application Areas

  Developmental and reproductive toxicity

  Germline studies

  High-resolution neuronal imaging

  Mutant screening

  Time-lapse imaging of developmental and cell division events

  RNAi and compound screening

• 详细参数

  Specification
  Pressure range (built-in pump): 0 to 10 psi (gauge)
  Pressure range (opt. external source): 0 to 30 psi (gauge)
  Sensing bias: <0.1 psi
  Sensing resolution: ±0.002 psi
  Pressure accuracy: ±7% 0.1 to 0.5 psi, ±2% 0.5 to 1 psi, ±1% greater than 1 psi
  Pressure stability: ±0.01 psi
  Pressure channels: 2
  Max flow rate*: 1000 mL/min
  

• 产品特色

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• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。