Rainbow R6 In-Situ Fiber Optic UV-Vis Spectrometer

• 详细介绍
• 详细参数

• 详细介绍

  RAINBOW Multichannel UV-Visible Fiber Optic In-Line Concentration Monitoring System
  Rainbow is a system that uses fiber optic probes for in-line concentration monitoring. It enables real-time measurement of solution concentration and concentration changes without the need for sampling. The system can be integrated with various types of dissolution and permeation testing workstations for determining solubility, dissolution rate, permeability, and supersaturation/precipitation. Data collection and analysis are simple and convenient. The system can be configured with up to 8 independent fiber optic channels, with a spectral acquisition range of 200–720 nm, and supports concentration monitoring at intervals as fast as every 2 seconds.
  
  Drug Dissolution and Permeation Absorption Equipment
  Permeation Flux (FLUX) Testing Platform: By inserting the Rainbow fiber optic probe into a dual-chamber system separated by a biomimetic membrane, this small-volume permeation experiment evaluates the in vitro absorption potential of different formulations. By measuring transmembrane permeation flux, a more accurate in vitro–in vivo correlation can be established.
  The Rainbow fiber optic in-line concentration monitoring system can be integrated into various types of drug dissolution and permeation absorption testing platforms, ranging from small-volume systems with limited sample quantities to physiologically relevant volume systems. Configurations include microDISS, miniDISS, MicroFLUX, MacroFLUX, and BioFLUX. These platforms provide precise temperature control and automatic stirring, and integrate seamlessly with Rainbow to allow simultaneous evaluation of drug dissolution and permeability in a single experiment.
  
  SCISSOR – Subcutaneous Injection Simulation Dissolution and Permeation System
  SCISSOR is the world's first scientific instrument specifically designed for subcutaneous injection drug formulation development. It enables in vitro evaluation of the release behavior of long-acting formulations. The system simulates the environment and pressure conditions of subcutaneous tissue, monitors drug precipitation or aggregation caused by environmental transitions, and evaluates post-injection drug stability.
  By measuring the dissolution–permeation profiles of drugs under physiologically relevant conditions, SCISSOR enables ranking of different formulations by absorption potential and establishes in vitro–in vivo correlation, accelerating your subcutaneous formulation development process. SCISSOR can reduce the number of animal studies required and is applicable not only to large molecule biologics such as monoclonal or bispecific antibodies and peptides, but also to small molecule drug formulations such as micro/nano formulations, microspheres, implants, and in situ gels.
  
  SIRIUS T3 – Instrument for Determining Physicochemical Properties of Drugs – A Must-Have for High-Throughput Compound Screening
  Sirius T3 requires only microgram-level sample amounts and uses potentiometric titration and UV spectroscopic BEE high-pressure homogenization titration to measure the dissociation constant (pKa), partition coefficient (logP/D), and solubility of ionizable drugs. For poorly soluble compounds, Sirius T3 can incorporate multiple solubilizers to enable determination of physicochemical properties.
  This system is an ideal tool for early compound screening, physicochemical characterization, and pre-formulation studies. With a high degree of automation, it performs complex programmed measurements through automatic reagent addition, stirring, spectrum collection, pH measurement, and temperature control. It is recognized as the “gold standard” in the industry for determining physicochemical constants of drugs.
  
  BEE High-Pressure Homogenizer
  From small-scale R&D to large-scale production, Pion’s high-pressure homogenizers deliver excellent fluid processing capabilities, enabling particle size reduction (micronization), cell disruption, and the preparation of stable micro/nano emulsions and dispersions.
  The modular interaction chamber design significantly reduces trial numbers and shortens product development timelines. Additionally, BEE emphasizes system scalability, enabling seamless transition from laboratory to commercial production. It is widely trusted by global pharmaceutical, biotechnology, chemical, food, and beverage manufacturers.
  
  PREPENGINE High-Speed Stirrer
  Compact benchtop design with 2-position or 10-position independently powered high-output stirring stations.
  The parallel artificial membrane permeability assay (PAMPA) kit allows rapid and uniform sample preparation, offering a 90% speed improvement over traditional methods. It is widely used in pretreatment experiments for solid dosage forms, traditional Chinese medicine, and food.
  This high-power stirring station maximizes efficiency and accelerates the sample preparation process. Users can customize stirring time, with adjustable stirring speeds from 500 to 6000 rpm.
  Main application areas include impurity testing and formulation content uniformity analysis.
  
  Parallel Artificial Membrane Permeability Assay (PAMPA) Kit
  Pion’s PAMPA technology uses a range of artificial biomimetic membranes to simulate human physiological conditions. Through the use of 96-well plates and classical models and protocols, it enables in vitro measurement of API permeability and evaluation of absorption behavior of different formulations.
  PAMPA is applicable for compound permeability screening during drug discovery, excipient selection in pre-formulation, and comparative permeation flux studies. By measuring drug concentrations on both sides of the biomimetic membrane, it evaluates drug absorption behavior and provides a more realistic in vitro–in vivo correlation.
  
  Product Advantages:
  In-Situ Fiber Optic UV-Vis Spectrometer for Dissolution, Absorption, Flux and Solubility Studies
  Predict how a drug will be released in the body prior to animal studies.
  Abandon or optimize lead compounds with confidence.
  Sample measurement can be obtained in less than 5 seconds
  Product Key Features:
  The Software for the Rainbow R6
  Pion Predictor‍: An enhanced data processing and management platform that allows you to analyze dissolution and flux data to get dissolution rates, precipitation kinetics, and predicted fraction absorbed ratio.
  AuPRO: for data collection and refinement in research and development:A powerful analytical software designed specifically for the needs of early stage compound screening, and during pre-formulation and formulation development.‍
  DissoPRO: for method development and quality control. A secure, traceable software package designed to address the needs of dissolution scientists and quality groups in highly regulated environments.
  Application：
  The Rainbow R6 is the core technology in Pion’s portfolio of dissolution solutions for:
  Dissolution testing
  Drug solubility
  Dissolution monitoring - just add a small volume dissolution tester to your Rainbow R6:
  MicroDISS - small volumes of 2- 20 ml
  MiniDISS - biorelevant volumes of 100-250 ml
  Absorption and Flux assays - just add FLUX apparatus to your Rainbow R6:
  MicroFLUX using only several milligrams of sample for early-stage development where sample is limited
  BioFLUX at biorelevant  volumes (200-250mL) for late stage formulation development
  MacroFLUX for a 900mL vessel of a USP II apparatus designed for use in formulation development based on standard USP dissolution setups
  

• 详细参数

  Specification
  MicroDISS system consists of R6 and MicroSample Platform for studying drug dissolution behavior with minimal API quantities. Experimental volumes range from 2 mL to 20 mL.
  MiniDISS system comprises R6 and miniDT small volume dissolution testers for physiological relevant dissolution curve determination. Dissolution cup volumes available in 100, 200, and 250 mL options.
  MicroFLUX system includes R6 and MicroSample Platform, FLUX dissolution-permeation assembly for drug flux dissolution-permeation experiments with limited sample quantities.
  MacroFLUX system combines R6 and standard 900 mL dissolution apparatus, FLUX dissolution-permeation assembly. MacroFLUX technology is compatible with various volumes of dissolution apparatus available in the market.
  BioFLUX system integrates R6 and 500 mL dissolution cups from pharmacopeial standards, FLUX dissolution-permeation assembly. BioFLUX technology is also compatible with different volumes of dissolution apparatus available in the market.
  Scissor N3 (or N6) is compatible with Rainbow B6 for in situ concentration detection in subcutaneous injection simulation systems.
  

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。

• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。