Discoverer™ Brillouin Microscope

• 详细介绍
• 详细参数

• 详细介绍

  Basic Information
  The Discoverer™ system is a newly developed add-on for motorized inverted or upright research microscopes. It is compatible with major microscope brands, including Zeiss, Leica, Olympus/Evident, and Nikon. The installation is quick and straightforward, taking only minutes to complete. The OptiBridge™ module from CellSense connects to a side port of the microscope body, seamlessly integrating the system. The motorized microscope body is fully utilized and controlled via the Discoverer™ software, enhancing the light microscope’s capabilities with a mechanical imaging channel for true multimodal imaging. Developed by experienced professionals in mechanobiology instrumentation, the Discoverer™ is ready to use..
  The Discoverer™ is designed for maximum mechanical and thermal stability, compatible with both inverted and upright microscopes for long-term experiments on living samples. It features the latest Brillouin technology, including a multi-stage interferometric spectrum detector, optimized beam path, high-quality optical components with perfected coatings, and innovative automation features. The Discoverer™ is a masterpiece of engineering. Its revolutionary software design enables users to obtain quick results without being experts. It offers a wide range of accessories, modes, and features, providing unparalleled flexibility for any application.
  The Discoverer™ system is a newly developed add-on for motorized inverted or upright research microscopes. It is compatible with major microscope brands, including Zeiss, Leica, Olympus/Evident, and Nikon. The installation is quick and straightforward, taking only minutes to complete. The OptiBridge™ module from CellSense connects to a side port of the microscope body, seamlessly integrating the system. The motorized microscope body is fully utilized and controlled via the Discoverer™ software, enhancing the light microscope’s capabilities with a mechanical imaging channel for true multimodal imaging. Developed by experienced professionals in mechanobiology instrumentation, the Discoverer™ is ready to use.
  
  Product Advantages:
  High-resolution and label-free imaging
  Utilizing Brillouin microscopy technology, it enables non-invasive, label-free 3D mechanical property measurements of living cells, organoids, tissues, and small organisms.
  Automation and ease of use
  Employs intelligent workflow software such as FlowPlanner™ and PerfectOverlay™ to simplify operation, allowing users with little to no Brillouin microscopy experience to quickly obtain high-quality data.
  Multimodal imaging integration
  Seamlessly integrates with major inverted or upright microscopes, enabling simultaneous use with brightfield, phase contrast, DIC, fluorescence, and confocal imaging to perfectly combine mechanical information with optical imaging.
  Strong compatibility with environmental control
  Supports various environmental control devices, suitable for long-term live cell imaging experiments to ensure samples are measured under optimal conditions.
  High sensitivity and stability
  Uses a low-phototoxicity 780 nm near-infrared laser to minimize sample damage; the system is designed with mechanical and thermal stability for long-term experiments.
  Powerful automation features
  Includes automated calibration, autofocus, and large-area mapping (MultiMap™), reducing human error and improving data reliability and experimental efficiency.
  Compatible with major microscope brands
  Fits with mainstream microscopes such as Zeiss, Leica, Nikon, and Olympus, making it easy to integrate into existing experimental platforms.
  Main Product Features:
  1. Label-Free, Non-Invasive Imaging
  Utilizes Brillouin scattering to measure mechanical properties without fluorescence labeling or damaging live samples.
  2. 3D Mechanical Imaging Capability
  Offers high-resolution 3D mechanical mapping of cells, organoids, tissues, and small organisms.
  3. Highly Automated and User-Friendly
  Equipped with intuitive software like FlowPlanner™ and PerfectOverlay™, enabling easy setup and operation—even for beginners.
  4. Strong Multimodal Compatibility
  Seamlessly integrates with brightfield, fluorescence, DIC, and confocal imaging for correlated optical and mechanical data.
  5. Environmental Control Support
  Compatible with temperature, CO₂, and humidity control systems for long-term live imaging applications.
  6. High Sensitivity and Low Phototoxicity
  Uses a 780 nm near-infrared laser to minimize photodamage, ideal for long-term observation of sensitive samples.
  7. Advanced Data Processing and Visualization
  Includes powerful features such as data fitting, edge detection, 3D rendering, and cross-sectional analysis, with batch processing support.
  8. Modular Design with Broad Microscope Compatibility
  Easily integrates with leading inverted and upright microscopes from Zeiss, Nikon, Leica, and Olympus, allowing easy system upgrades.
  Application Areas:
  1. 3D Cell Culture & Mechanobiology
  Non-invasive, label-free measurement of the mechanical properties of spheroids and organoids.
  Real-time monitoring of tumor organoids (e.g., MCF‑7 breast cancer) within 3D microenvironments.
  Analysis of how cells respond to different mechanical conditions in terms of invasiveness, proliferation, and differentiation.
  Investigation of time-dependent mechanical changes in organoid-based disease models.
  2. Complex Tissue Mechanics
  Subcellular-resolution 3D mechanical imaging of living tissues.
  Suitable for mechanobiological research from single cells to whole small organisms (e.g., zebrafish embryos).
  Applied in developmental biology, regenerative medicine, and tissue repair studies.
  3. Plant Physiology
  Real-time assessment of mechanical properties in plant tissues such as root tips and leaves.
  Correlation with brightfield imaging to localize mechanical changes (e.g., cell wall thickening).
  Supports studies on plant growth regulation, stress responses, and nutrient uptake mechanisms.
  4. Soft Materials & Hydrogels
  Quantitative analysis of stiffness and viscoelasticity in soft biomaterials such as hydrogels and Matrigel.
  Ideal for evaluating scaffolds in tissue engineering, biomaterial development, and drug delivery platforms.
  Allows in situ mechanical mapping of cell-laden hydrogels without additional sample preparation.
  
  
  
  

• 详细参数

  Specification
  Basic Configuration
  Laser module
  Spectrometer module
  OptiBridge™ module
  PC and software
  System Specifications
  Integrated closed-box system, with highest mechanical and thermal stability
  Advanced fiber coupling to existing inverted or upright light microscopes
  Near IR laser excitation with 780 nm for lowest phototoxicity and uncompromised fluorescence
  Spectral resolution < 1 pm
  Highest detector sensitivity for fastest signal capture
  Transmission illumination with standard condensers for precise brightfield, DIC, and phase contrast
  Fully automated system setup and calibration
  Dimensions of laser module and spectrometer module (both stackable): 110 × 65 × 24 cm³
  Dimension of OptiBridge™: 42×40×15 cm³
  Optical Configurations
  Fits on inverted motorized microscopes from:
  Zeiss (Axio Observer line)
  Olympus/Evident (IXplore line)
  Nikon (Ti2 line)
  Leica (DMi line)
  Compatible with upright motorized fluorescence microscopes combined with Brillouin from:
  Zeiss (Axio Imager)
  Olympus/Evident (BX)
  Leica (DM line)
  Nikon (Ni line)
  Brillouin simultaneously with other light microscopy methods
  Fully simultaneous operation with optical phase contrast and DIC using standard condensers
  Combine Brillouin with advanced commercial confocal microscopes and all advanced fluorescence optical techniques
  Stages and Sample Holders
  Compatibility with motorized stages is available for all major inverted optical microscope manufacturers such as Zeiss, Nikon, Olympus/Evident, and Leica
  New Workflow-Based Discoverer™ Software
  Revolutionary user experience with the new interface design
  True multi-user platform, perfect for imaging facilities
  New PerfectOverlay™ for combined optical and Brillouin or other information
  MultiMap™ for multiple area mapping
  FlowPlanner™ for designing a specific measurement workflow
  Powerful Data Processing (DP) with full functionality for:
  Data export
  Fitting
  Filtering
  Edge detection
  3D rendering
  Cross-sectioning
  Powerful batch processing of images and other analyses
  Standard Operating Modes: Brillouin Operation
  Brillouin mapping with Brillouin shift and linewidth
  Advanced stiffness and viscosity mapping
  PerfectOverlay™ for combining Brillouin and other optical images
  Optical Imaging Modes
  Brightfield imaging
  Basic widefield fluorescence
  Optional Modes and Accessories
  FlowControl™ feature for remote experiment control
  Wellplate mapping function
  Epi-Fluorescence import function
  Environmental control options
  Additional XY or Z sample movement stages available

• 产品特色

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• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。