Tessie High-Throughput Nanoneedle Multi-Omics Detection System

• 详细介绍
• 详细参数

• 详细介绍

  Basic Information
  This is an automated multiomic analytical platform based on NanoNeedle photonic sensing technology, designed for ultra-sensitive analysis of proteins, nucleic acids, and AAV gene therapy vectors. The system utilizes densely integrated functionalized nanoneedle structures on a chip surface to capture target molecules and generate optical signals for highly sensitive detection. It enables simultaneous quantification of viral capsids and transgenes within a single workflow, while differentiating full, partial, and empty AAV particles and identifying genome truncation events as critical quality attributes. The platform integrates automated instrumentation, microplate consumables, and cloud-based analytics software to provide high throughput, minimal sample consumption, broad dynamic range, and ultra-high sensitivity, while supporting both crude and purified samples. Unlike conventional ELISA, qPCR, ddPCR, or NGS workflows, the platform combines protein analysis, nucleic acid analysis, viral vector integrity assessment, and multiomic characterization on a single system, making it highly suitable for AAV gene therapy development, CMC process optimization, GMP quality control, viral vector characterization, biomarker discovery, ultra-low abundance protein detection, and precision medicine applications.
  The platform has been designated by the U.S. Food and Drug Administration (FDA) as an Advanced Manufacturing Technology (AMT), supporting quality analytics and process optimization in gene therapy development and manufacturing. This designation highlights the technology’s value in improving manufacturing efficiency, strengthening quality control, and accelerating regulatory review, particularly for critical quality attribute assessment and GMP release testing of AAV and other gene therapy vectors.
  Product Advantages:
  ·  Simultaneous protein and nucleic acid analysis on one platform
  ·  Superior discrimination of full, partial, and empty AAV capsids
  ·  fg/mL-level sensitivity
  ·  Requires as little as 2 µL sample volume
  ·  Compatible with crude and purified samples
  ·  Simultaneous capsid and genome quantification reduces assay-to-assay bias
  ·  High-throughput workflow with 96- and 384-well compatibility
  ·  FDA/CBER Advanced Manufacturing Technology (AMT) designated for gene therapy QC applications
  
  Main Product Features:
  1. Nanoneedle photonic sensing technology enabling ultra-high sensitivity detection
  Based on a nanoneedle array photonic sensing principle, each nanoneedle serves both as a molecular capture site and a signal transduction element, enabling highly sensitive detection without the need for extensive amplification steps. The system achieves femtogram-per-milliliter (fg/mL) sensitivity, making it suitable for ultra-low abundance biomarker and viral load analysis.
  2. Simultaneous protein and nucleic acid detection for true integrated multi-omics analysis
  The platform enables concurrent quantification of proteins and nucleic acids within a single workflow, delivering unified multi-omics data output. This eliminates data fragmentation caused by separate analytical systems and significantly improves consistency, comparability, and overall analytical efficiency.
  3. Comprehensive AAV vector integrity characterization capability
  In a single assay, the system can quantify full, partial, and empty AAV capsids while simultaneously assessing genome integrity, including full-length versus truncated transgene analysis. This provides critical quality attributes for gene therapy development, process optimization, and manufacturing quality control.
  4. High sample compatibility with minimal sample preparation requirements
  The platform supports direct analysis of both crude and purified samples without requiring extensive purification or enrichment procedures. This significantly reduces sample preparation time and operator-induced variability, making it highly suitable for high-throughput screening and industrial QC workflows.
  5. High-throughput automated platform designed for R&D and GMP manufacturing
  With compatibility for 96- and 384-well plate formats, combined with automated reading and cloud-based data analysis, the system enables a fully standardized workflow from assay execution to data output. It is well suited for applications ranging from early-stage research to CMC development and GMP quality control environments.
  Application Areas:
  1.AAV gene therapy development and QC/CMC: Enables precise analysis of capsid composition, genome integrity, and vector titer across the AAV production workflow.
  2.CGT process development: Monitors critical quality attributes and provides rapid feedback for optimizing cell and gene therapy manufacturing processes.
  3.Biomarker discovery and validation: Detects ultra-low abundance protein and nucleic acid biomarkers for early disease detection and translational research.
  4.Precision medicine and companion diagnostics: Supports multi-parameter profiling for patient stratification and treatment response prediction.
  5.Drug discovery and high-throughput screening: Enables target validation and compound screening in multiplex, high-throughput drug development workflows.
  6.Virology and infectious disease research: Supports viral load quantification and structural integrity analysis for vaccine and infection studies.
  7.Multi-omics and systems biology research: Integrates protein and nucleic acid analysis to decode complex biological regulatory networks.
  

• 详细参数

  Specification
  Sensitivity：fg/mL
  Minimum Sample Volume：2 µL
  Dynamic Range：7 logs
  Throughput：96 / 384 wells
  Multiplexing Capability：96,000
  Runtime：2–3 hours
  Hands-on Time：<30 minutes
  Sample Compatibility：Crude and purified samples
  Target Types：Proteins and nucleic acids
  AAV Capability：Simultaneous capsid and transgene analysis
  
  

• 产品特色

  因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。

• 详细介绍

  AutoCal系统提供在线的机器人校准方案，旨在快速和自动地保证机械设备的工作性能。因用于机器人各方面应用且与大多数机器人类型兼容，AutoCal系统可以检测出机器人自身构造和工具中心点（TCP）的 突然改变或偏离，并且该系统无需人为干涉就自动地更正这些误差。这意味着不用猜测哪里会出错，不用浪费宝贵时间在机器人程序重复校准上，产品品质无任何损失。

  AutoCal系统-Dynalog的先进水平校准技术，Dynalog是机器人单元标定技术的世界领导者。它的主流产品DynaCal 系统，被应用于离线的机器人单元校准，并作为最精确的和技术先进的机器人校准程序为许多机器人制造商和终端使用者所接受。AutoCal 系统将已证实的DynaCal校准技术结合到一个在线的全自动系统中，该系统专为程序控制和复原而设计的，价格低廉。