Breaking the Bottleneck in Single-Cell Proteomic Sample Preparation: The celleno

In single-cell proteomics (SCP) research, sample preparation serves as the "first checkpoint" that determines the quality of subsequent mass spectrometry analysis. Traditional methods rely on manual picking of single cells, flow cytometry sorting of singl...

09-23

2025

An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per

Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE protocol for loss-reduced tissue proc...

08-08

2025

Single-cell proteomic characterization of drug-resistant prostate cancer cells u

This study employs single-cell proteomics to analyze the heterogeneity of prostate cancer drug-resistant cells. The optimized cellenONE protocol enables the isolation of large multi-aneuploid DRCs. Three proteomic DRC subtypes associated with size and fun...

07-28

2025